Physiologically-based pharmacokinetic modeling (PBPK) is a mathematical modeling technique for prediction of the absorption, distribution, metabolism and excretion (ADME) of a compound in humans and other species used in pharmaceutical research.
ADME describes the disposition of a pharmaceutical compound within an organism. The four parameters influence the performance and pharmacological activity of the compound as a drug. PBPK or ADME modeling or ADME modeling or ADME prediction will be provided as shown below.
Our computer calculations we provided to estimate preclinical or non-clinical ADME parameters including:
- Absorption – maximum fraction absorbed, fraction absorbed, bioavailability.
- Distribution – organ/plasma partition coefficients and volume of distribution in steady state, concentration time curves in plasma and organs, active transport.
- Metabolism – predicting pharmacokinetic behavior on the basis of metabolism rates.
- Excretion – ways of excretion, enterohepatic cycle.
- Sensitivity analysis for interactions and individual variations.
- Pharmaceutical application – assessment of the best pharmaceutical form.
